For World Cup 2022, and the potential to win the whole thing, the following is a solid option to consider. Note the skillful back four.
Weah Wood Sargent
Pulisic* Nagbe* Nguyen
Amon Bradley Ream Shea
Guzan
Key Bench:
Feilhaber
Johannsson
Torres
Adams
Arriola
Acosta
Trapp
Cameron
Besler
Yedlin
* When healthy.